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1.
Epilepsia ; 61(11): 2572-2582, 2020 11.
Article in English | MEDLINE | ID: mdl-33015831

ABSTRACT

OBJECTIVE: Previous studies have shown the effectiveness of manual-based treatment for psychogenic nonepileptic seizures (PNES), but access to mental health care still remains a problem, especially for patients living in areas without medical professionals who treat conversion disorder. Thus, we evaluated patients treated with cognitive behavioral therapy-informed psychotherapy for seizures with clinical video telehealth (CVT). We evaluated neuropsychiatric and seizure treatment outcomes in veterans diagnosed with PNES seen remotely via telehealth. We hypothesized that seizures and comorbidities will improve with treatment. METHODS: This was a single-arm, prospective, observational, cohort, consecutive outpatient study. Patients with video-electroencephalography-confirmed PNES (n = 32) documented their seizure counts daily and comorbid symptoms prospectively over the course of treatment. Treatment was provided using a 12-session manual-based psychotherapy treatment given once per week, via CVT with a clinician at the Providence Veterans Affairs Medical Center. RESULTS: The primary outcome, seizure reduction, was 46% (P = .0001) per month over the course of treatment. Patients also showed significant improvements in global functioning (Global Assessment of Functioning, P = < .0001), quality of life (Quality of Life in Epilepsy Inventory-31, P = .0088), and health status scales (Short Form 36 Health Survey, P < .05), and reductions in both depression (Beck Depression Inventory-II, P = .0028) and anxiety (Beck Anxiety Inventory, P = .0013) scores. SIGNIFICANCE: Patients with PNES treated remotely with manual-based seizure therapy decreased seizure frequency and comorbid symptoms and improved functioning using telehealth. These results suggest that psychotherapy via telehealth for PNES is a viable option for patients across the nation, eliminating one of the many barriers of access to mental health care.


Subject(s)
Cognitive Behavioral Therapy/methods , Psychophysiologic Disorders/therapy , Seizures/therapy , Telemedicine/methods , Veterans , Video Recording/methods , Adolescent , Adult , Aged , Aged, 80 and over , Cohort Studies , Female , Humans , Male , Middle Aged , Prospective Studies , Psychophysiologic Disorders/diagnosis , Psychophysiologic Disorders/psychology , Seizures/diagnosis , Seizures/psychology , Treatment Outcome , Veterans/psychology , Young Adult
3.
J Neuropsychiatry Clin Neurosci ; 32(3): 294-301, 2020.
Article in English | MEDLINE | ID: mdl-32054400

ABSTRACT

OBJECTIVE: The authors compared baseline characteristics and reporting of psychosocial measures among veterans with seizures who were evaluated in-clinic or remotely via computer video telehealth (CVT). It was hypothesized that the CVT group would report less trauma history, drug use, and comorbid symptoms compared with veterans seen in-clinic. METHODS: A cross-sectional design was used to compare 72 veterans diagnosed with psychogenic nonepileptic seizures (PNES) or concurrent mixed epilepsy and PNES who were consecutively evaluated by a single clinician at the Providence Veterans Affairs Medical Center (PVAMC) Neuropsychiatric Clinic. In-clinic evaluations of veterans were performed at the PVAMC Neuropsychiatric Clinic (N=16), and remote evaluations of veterans referred to the VA National TeleMental Health Center were performed via CVT (N=56). All 72 patients were given comprehensive neuropsychiatric evaluations by direct interview, medical examination, and medical record review. Veterans' reporting of trauma and abuse history, drug use, and psychiatric comorbidities was assessed, along with neurologic and psychiatric variables. RESULTS: No significant differences were found between veterans evaluated in-clinic or remotely with regard to baseline characteristics and reporting of potentially sensitive information, including trauma and abuse history, substance use, and comorbid symptoms. CONCLUSIONS: Veterans with PNES evaluated via telehealth did not appear to withhold sensitive or personal information compared with those evaluated in-clinic, suggesting that CVT may be a comparable alternative for conducting evaluations. Baseline evaluations are used to determine treatment suitability, and telehealth allows clinicians to gain access to important information that may improve or inform care.


Subject(s)
Conversion Disorder/diagnosis , Epilepsy/diagnosis , Interview, Psychological , Mental Health Services , Seizures/diagnosis , Self Report , Telemedicine , Adult , Comorbidity , Cross-Sectional Studies , Female , Humans , Interview, Psychological/standards , Male , Mental Health Services/standards , Middle Aged , Self Report/standards , Telemedicine/standards , United States , United States Department of Veterans Affairs , Veterans
4.
J Med Internet Res ; 20(11): e11350, 2018 11 07.
Article in English | MEDLINE | ID: mdl-30404771

ABSTRACT

BACKGROUND: Access to mental health care is challenging. The Veterans Health Administration (VHA) has been addressing these challenges through technological innovations including the implementation of Clinical Video Telehealth, two-way interactive and synchronous videoconferencing between a provider and a patient, and an electronic patient portal and personal health record, My HealtheVet. OBJECTIVE: This study aimed to describe early adoption and use of My HealtheVet and Clinical Video Telehealth among VHA users with mental health diagnoses. METHODS: We conducted a retrospective, cross-sectional analysis of early My HealtheVet adoption and Clinical Video Telehealth engagement among veterans with one or more mental health diagnoses who were VHA users from 2007 to 2012. We categorized veterans into four electronic health (eHealth) technology use groups: My HealtheVet only, Clinical Video Telehealth only, dual users who used both, and nonusers of either. We examined demographic characteristics and mental health diagnoses by group. We explored My HealtheVet feature use among My HealtheVet adopters. We then explored predictors of My HealtheVet adoption, Clinical Video Telehealth engagement, and dual use using multivariate logistic regression. RESULTS: Among 2.17 million veterans with one or more mental health diagnoses, 1.51% (32,723/2,171,325) were dual users, and 71.72% (1,557,218/2,171,325) were nonusers of both My HealtheVet and Clinical Video Telehealth. African American and Latino patients were significantly less likely to engage in Clinical Video Telehealth or use My HealtheVet compared with white patients. Low-income patients who met the criteria for free care were significantly less likely to be My HealtheVet or dual users than those who did not. The odds of Clinical Video Telehealth engagement and dual use decreased with increasing age. Women were more likely than men to be My HealtheVet or dual users but less likely than men to be Clinical Video Telehealth users. Patients with schizophrenia or schizoaffective disorder were significantly less likely to be My HealtheVet or dual users than those with other mental health diagnoses (odds ratio, OR 0.50, CI 0.47-0.53 and OR 0.75, CI 0.69-0.80, respectively). Dual users were younger (53.08 years, SD 13.7, vs 60.11 years, SD 15.83), more likely to be white, and less likely to be low-income than the overall cohort. Although rural patients had 17% lower odds of My HealtheVet adoption compared with urban patients (OR 0.83, 95% CI 0.80-0.87), they were substantially more likely than their urban counterparts to engage in Clinical Video Telehealth and dual use (OR 2.45, 95% CI 1.95-3.09 for Clinical Video Telehealth and OR 2.11, 95% CI 1.81-2.47 for dual use). CONCLUSIONS: During this study (2007-2012), use of these technologies was low, leaving much potential for growth. There were sociodemographic disparities in access to My HealtheVet and Clinical Video Telehealth and in dual use of these technologies. There was also variation based on types of mental health diagnosis. More research is needed to ensure that these and other patient-facing eHealth technologies are accessible and effectively used by all vulnerable patients.


Subject(s)
Mental Health/trends , Patient Portals/trends , Telemedicine/methods , United States Department of Veterans Affairs/trends , Veterans Health/trends , Videoconferencing/trends , Adolescent , Adult , Aged , Aged, 80 and over , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Retrospective Studies , United States , Young Adult
5.
Telemed J E Health ; 24(1): 45-53, 2018 01.
Article in English | MEDLINE | ID: mdl-28665773

ABSTRACT

BACKGROUND: Telemental health interventions have empirical support from clinical trials and structured demonstration projects. However, their implementation and sustainability under less structured clinical conditions are not well demonstrated. INTRODUCTION: We conducted a follow-up analysis of the implementation and sustainability of a clinical video teleconference-based collaborative care model for individuals with bipolar disorder treated in the Department of Veterans Affairs to (a) characterize the extent of implementation and sustainability of the program after its establishment and (b) identify barriers and facilitators to implementation and sustainability. MATERIALS AND METHODS: We conducted a mixed methods program evaluation, assessing quantitative aspects of implementation according to the Reach, Efficacy, Adoption, Implementation, and Maintenance implementation framework. We conducted qualitative analysis of semistructured interviews with 16 of the providers who submitted consults, utilizing the Integrated Promoting Action on Research Implementation in the Health Services implementation framework. RESULTS: The program demonstrated linear growth in sites (n = 35) and consults (n = 915) from late 2011 through mid-2016. Site-based analysis indicated statistically significant sustainability beyond the first year of operation. Qualitative analysis identified key facilitators, including consult content, ease of use via electronic health record, and national infrastructure. Barriers included availability of telehealth space, equipment, and staff at the sites, as well as the labor-intensive nature of scheduling. DISCUSSION: The program achieved continuous growth over almost 5 years due to (1) successfully filling a need perceived by providers, (2) developing in a supportive context, and (3) receiving effective facilitation by national and local infrastructure. CONCLUSION: Clinical video teleconference-based interventions, even multicomponent collaborative care interventions for individuals with complex mental health conditions, can grow vigorously under appropriate conditions.


Subject(s)
Bipolar Disorder/therapy , Patient Care Team/organization & administration , Telecommunications/organization & administration , Telemedicine/organization & administration , United States Department of Veterans Affairs/organization & administration , Cooperative Behavior , Electronic Health Records , Humans , Organizational Innovation , Patient Satisfaction , Program Evaluation , Qualitative Research , Quality of Health Care , United States
6.
Telemed J E Health ; 22(12): 1041-1046, 2016 12.
Article in English | MEDLINE | ID: mdl-27286369

ABSTRACT

BACKGROUND: Clinical video telehealth provides a means for increasing access to psychotherapy. Insomnia is prevalent, is associated with a number of negative sequelae, and can be effectively managed with cognitive behavioral treatment of insomnia (CBT-I). Telehealth technologies can provide a means for increasing access to CBT-I. MATERIALS AND METHODS: The Tele-Insomnia program is a Veterans Health Administration (VHA) initiative in which CBT-I is delivered in a group format by telehealth. Veterans received six weekly sessions of group CBT-I, completing the Insomnia Severity Index (ISI) and daily sleep diaries throughout treatment. Paired-samples t-tests were used to examine differences in each measure from the first to the last session of treatment. RESULTS: There were statistically and clinically significant improvements in the ISI and all sleep diary variables with the exception of total sleep time. Video quality was excellent, and there were few connectivity problems. CONCLUSIONS: Clinical video telehealth technology can be used to deliver group CBT-I in a manner that produces clinically significant improvement. This model is scalable and has been used to develop a national clinical telehealth program.


Subject(s)
Cognitive Behavioral Therapy/methods , Psychotherapy, Group/methods , Sleep Initiation and Maintenance Disorders/therapy , Telemedicine/methods , Adult , Aged , Feasibility Studies , Female , Health Services Accessibility , Humans , Male , Middle Aged , Patient Education as Topic , Pilot Projects , United States , United States Department of Veterans Affairs
7.
Telemed J E Health ; 22(10): 855-864, 2016 10.
Article in English | MEDLINE | ID: mdl-26906927

ABSTRACT

INTRODUCTION: Numerous randomized controlled trials indicate that collaborative chronic care models improve outcome in a wide variety of mental health conditions, including bipolar disorder. However, their spread into clinical practice is limited by the need for a critical mass of patients and specialty providers in the same locale. Clinical videoconferencing has the potential to overcome these geographic limitations. MATERIALS AND METHODS: A videoconference-based collaborative care program for bipolar disorder was implemented in the Department of Veterans Affairs. Program evaluation assessed experience with the first 400 participants, guided by five domains specified by the American Telemedicine Association: treatment engagement, including identification of subpopulations at risk for not being reached; participation in treatment; clinical impact; patient safety; and quality of care. RESULTS: Participation rates resembled those for facility-based collaborative care. No participant characteristics predicted nonengagement. Program completers demonstrated significant improvements in several clinical indices, without evidence of compromise in patient safety. Guideline-based quality of care assessment after 1 year indicated increased lithium use, decreased antidepressant use, and increased prazosin use in individuals with comorbid post-traumatic stress disorder, but no impact on already high rates of lithium serum level monitoring. DISCUSSION: Clinical videoconferencing can extend the reach of collaborative care models for bipolar disorder. The next step involves assessment of the videoconference-based collaborative care for other serious mental health conditions, investigation of barriers and facilitators of broad implementation of the model, and evaluation of the business case for deployment and sustainability in clinical practice.


Subject(s)
Bipolar Disorder/therapy , Patient Care Team/organization & administration , Telemedicine/organization & administration , Videoconferencing/organization & administration , Adult , Aged , Aged, 80 and over , Cooperative Behavior , Female , Humans , Male , Middle Aged , Program Evaluation , Quality Indicators, Health Care , United States , United States Department of Veterans Affairs
8.
Telemed J E Health ; 21(7): 564-6, 2015 Jul.
Article in English | MEDLINE | ID: mdl-25799233

ABSTRACT

OBJECTIVE: This study compares the mental health diagnoses of encounters delivered face to face and via interactive video in the Veterans Healthcare Administration (VHA). MATERIALS AND METHODS: We compiled 1 year of national-level VHA administrative data for Fiscal Year 2012 (FY12). Mental health encounters were those with both a VHA Mental Health Stop Code and a Mental Health Diagnosis (n=11,906,114). Interactive video encounters were identified as those with a Mental Health Stop Code, paired with a VHA Telehealth Secondary Stop Code. Primary diagnoses were grouped into posttraumatic stress disorder (PTSD), depression, anxiety, bipolar disorder, psychosis, drug use, alcohol use, and other. RESULTS: In FY12, 1.5% of all mental health encounters were delivered via interactive video. Compared with face-to-face encounters, a larger percentage of interactive video encounters was for PTSD, depression, and anxiety, whereas a smaller percentage was for alcohol use, drug use, or psychosis. CONCLUSIONS: Providers and patients may feel more comfortable treating depression and anxiety disorders than substance use or psychosis via interactive video.


Subject(s)
Mental Health , Telecommunications , Telemedicine , Veterans Health , Female , Humans , Interviews as Topic , Male , Mental Disorders
9.
Psychiatr Serv ; 63(11): 1131-3, 2012 Nov.
Article in English | MEDLINE | ID: mdl-23117510

ABSTRACT

OBJECTIVE: This is the first large-scale study to describe the types of telemental health services provided by the Veterans Health Administration (VHA). METHODS: The authors compiled national-level VHA administrative data for fiscal years 2006-2010 (October 1, 2005, to September 30, 2010). Telemental health encounters were identified by VHA and U.S. Department of Veterans Affairs stop codes and categorized as medication management, individual psychotherapy with or without medication management, group psychotherapy, and diagnostic assessment. RESULTS: A total of 342,288 telemental health encounters were identified, and each type increased substantially across the five years. Telepsychotherapy with medication management was the fastest growing type of telemental health service. CONCLUSIONS: The use of videoconferencing technology has expanded beyond medication management alone to include telepsychotherapy services, including both individual and group psychotherapy, and diagnostic assessments. The increase in telemental health services is encouraging, given the large number of returning veterans living in rural areas.


Subject(s)
Mental Health Services/statistics & numerical data , Telemedicine/statistics & numerical data , United States Department of Veterans Affairs , Humans , Mental Disorders/therapy , Psychotherapy/methods , Psychotherapy/statistics & numerical data , United States , Veterans/psychology
11.
Psychiatr Serv ; 63(4): 383-5, 2012 Apr.
Article in English | MEDLINE | ID: mdl-22476305

ABSTRACT

OBJECTIVE: The study assessed clinical outcomes of 98,609 mental health patients before and after enrollment in telemental health services of the U.S. Department of Veterans Affairs between 2006 and 2010. METHODS: The study compared number of inpatient psychiatric admissions and days of psychiatric hospitalization among patients who participated in remote clinical videoconferencing during an average period of six months before and after their enrollment in the telemental health services. RESULTS: Between 2006 and 2010, psychiatric admissions of telemental health patients decreased by an average of 24.2% (annual range 16.3%-38.7%), and the patients' days of hospitalization decreased by an average of 26.6% (annual range 16.5%-43.5%). The number of admissions and the days of hospitalization decreased for both men and women and in 83.3% of the age groups. CONCLUSIONS: This four-year study, the first large-scale assessment of telemental health services, found that after initiation of such services, patients' hospitalization utilization decreased by an average of approximately 25%.


Subject(s)
Hospitalization/statistics & numerical data , Mental Disorders/therapy , Outcome Assessment, Health Care , Telemedicine/statistics & numerical data , Adult , Aged , Aged, 80 and over , Female , Hospitalization/trends , Humans , Male , Mental Disorders/epidemiology , Middle Aged , United States , United States Department of Veterans Affairs , Veterans/psychology , Videoconferencing
12.
J Telemed Telecare ; 18(1): 17-9, 2012 Jan.
Article in English | MEDLINE | ID: mdl-22052966

ABSTRACT

In 2007, the VA Connecticut Healthcare System began a home electronic messaging programme for mental health patients. During the first two years, 76 patients with diagnoses of schizophrenia, post traumatic stress disorder, depression and substance-use disorders received a home messaging device, which was connected via an ordinary telephone line. There were daily questions, which were based on disease management protocols, and included alerts, data and educational components. Patient data were sent to a nurse practitioner each day for triage and follow-up. Patients used the device for at least six months. In the six months prior to enrolment, 42 patients were hospitalized for 46 admissions. In the following six months, six patients were hospitalized for nine admissions (P < 0.0001). In the six months prior to enrolment, 47 patients had a total of 80 ER visits. In the following six months, 16 patients had a total of 32 ER visits (P < 0.0001). Questionnaire responses indicated a high level of satisfaction with the home messaging programme.


Subject(s)
Community Mental Health Services/methods , Electronic Mail , Telemedicine/methods , Adult , Aged , Aged, 80 and over , Community Mental Health Services/standards , Depression/therapy , Feasibility Studies , Female , Hospitalization/statistics & numerical data , Humans , Male , Middle Aged , Outcome Assessment, Health Care , Patient Satisfaction , Schizophrenia/therapy , Stress Disorders, Post-Traumatic/therapy , Substance-Related Disorders/therapy , Surveys and Questionnaires
14.
Acad Med ; 85(7): 1171-81, 2010 Jul.
Article in English | MEDLINE | ID: mdl-20305532

ABSTRACT

PURPOSE: To develop a survey instrument designed to quantify supervision by attending physicians in nonprocedural care and to assess the instrument's feasibility and reliability. METHOD: In 2008, the Department of Veterans Affairs (VA) Office of Academic Affiliations convened an expert panel to adopt a working definition of attending supervision in nonprocedural patient care and to construct a survey to quantify it. Feasibility was field-tested on residents and their supervising attending physicians at primary care internal medicine clinics at the VA Loma Linda Healthcare System in their encounters with randomly selected outpatients diagnosed with either major depressive disorder or diabetes. The authors assessed both interrater concurrent reliability and test-retest reliability. RESULTS: The expert panel adopted the VA's definition of resident supervision and developed the Resident Supervision Index (RSI) to measure supervision in terms of residents' case understanding, attending physicians' contributions to patient care through feedback to the resident, and attending physicians' time (minutes). The RSI was field-tested on 60 residents and 37 attending physicians for 148 supervision episodes from 143 patient encounters. Consent rates were 94% for residents and 97% for attending physicians; test-retest reliability intraclass correlations (ICCs) were 0.93 and 0.88, respectively. Concurrent reliability between residents' and attending physicians' reported time was an ICC of 0.69. CONCLUSIONS: The RSI is a feasible and reliable measure of resident supervision that is intended for research studies in graduate medical education focusing on education outcomes, as well as studies assessing quality of care, patient health outcomes, care costs, and clinical workload.


Subject(s)
Clinical Competence , Internal Medicine/education , Internship and Residency , United States Department of Veterans Affairs/organization & administration , Adult , Aged , Feasibility Studies , Feedback, Psychological , Female , Health Care Surveys , Humans , Male , Middle Aged , Organization and Administration/statistics & numerical data , Surveys and Questionnaires , United States
15.
J Telemed Telecare ; 15(1): 51-4, 2009.
Article in English | MEDLINE | ID: mdl-19139221

ABSTRACT

When visiting patients with serious mental illness at their homes, case managers carried a portable videophone. This was used to access the hospital clinical team via the home telephone line, when an acute clinical need arose in addressing questions related to medication management and treatment planning; travel was therefore avoided. In an acceptability study lasting 12 months, 24 patients received the supplemental videophone mental health service and 19 of them completed a satisfaction survey. Only one patient was not satisfied with the videophone treatment, while 74% of them were very satisfied. Specific areas of satisfaction concerned the savings of time and travel, assistance with medication questions and increased involvement in treatment. No patient reported any difficulty in using the equipment. Staff members were enthusiastic about the decrease in travel time and there were no complaints about the videophone process or encounters. During the study, 135 h of the case manager's time was saved by using the videophone for urgent access visits, equivalent to a saving of $4000 in salary costs. In addition, the patients saved 135 h in travel time. We believe that there are other potential uses of videophones for seriously mentally ill patients, including discharge planning, intensive post-discharge monitoring and transition to community life.


Subject(s)
Home Care Services, Hospital-Based/organization & administration , Mental Disorders/therapy , Telemedicine , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Mental Disorders/psychology , Middle Aged , Patient Satisfaction , Telephone/instrumentation , Time Factors
16.
Behav Sci Law ; 26(3): 271-86, 2008.
Article in English | MEDLINE | ID: mdl-18548515

ABSTRACT

The Department of Veterans Affairs (VA) encompasses one of the largest telemental health networks in the world, with over 45,000 videoconferencing and over 5,000 home telemental health encounters annually. Recently, the VA designated suicide prevention as a major priority, with telehealth modalities providing opportunities for remote interventions. Suicide risk assessments, using videoconferencing, are now documented in the literature, as are current studies that find telemental health to be equivalent to face-to-face treatment. Remote assessment of suicidality, however, involves complex legal issues: licensing requirements for remote delivery of care, legal procedures for involuntary detainment and commitment of potentially harmful patients, and liability questions related to the remote nature of the mental health service. VA best practices for remote suicide risk assessment include paradigms for establishing procedures in the context of legal challenges (licensing and involuntary detainment/commitment), for utilizing clinical assessment and triage decision protocols, and for contingency planning to optimize patient care and reduce liability.


Subject(s)
Remote Consultation/legislation & jurisprudence , Suicide/legislation & jurisprudence , Veterans/legislation & jurisprudence , Videoconferencing/legislation & jurisprudence , Commitment of Mentally Ill/legislation & jurisprudence , Dangerous Behavior , Humans , Licensure, Medical/legislation & jurisprudence , Malpractice/legislation & jurisprudence , Outcome and Process Assessment, Health Care/legislation & jurisprudence , Quality Assurance, Health Care/legislation & jurisprudence , Risk Assessment/legislation & jurisprudence , Suicide/psychology , United States , Veterans/psychology , Suicide Prevention
17.
Article in English | MEDLINE | ID: mdl-15610956

ABSTRACT

In an open-label study, 13 patients taking depot antipsychotic medication for greater than 3 years were switched to oral olanzapine. The first 3-month experience has been previously reported. We now describe a second 3-month experience and integrate our observations into a cumulative 6-month report. Monthly, we assessed patients using clinical ratings [Positive and Negative Syndrome Scale (PANSS), Global Assessment of Functioning (GAF), Mini-Mental State Exam (MMSE), and Clinical Global Improvement Scale (CGI)] and side effect parameters [Abnormal Involuntary Movement Scale (AIMS), Association for Methodology and Documentation in Psychiatry psychotropic side effect rating scale (AMDP-5), and weights]. Olanzapine patients showed statistically significant improvement (baseline to endpoint sixth month) in GAF (p=0.015), MMSE (p=0.022), CGI improvement, and AIMS (p=0.038). There was no statistically significant change in PANSS, CGI severity, or AMDP-5 overall side effects. Weight gain over 6 months averaged 8.9 lb. All patients completed the study. Compliance was estimated at 90%, and 81% of patients chose to continue on the oral olanzapine. One patient was hospitalized at the conclusion of the study. Our findings suggest that clinicians may consider oral olanzapine as a viable alternative to depot antipsychotic medications, balancing clinical improvement in some clinical measures with lack of improvement in other clinical measures; and balancing improvement in abnormal involuntary movements with weight gain and its sequelae.


Subject(s)
Antipsychotic Agents/administration & dosage , Antipsychotic Agents/therapeutic use , Benzodiazepines/administration & dosage , Benzodiazepines/therapeutic use , Schizophrenia/drug therapy , Adult , Antipsychotic Agents/adverse effects , Benzodiazepines/adverse effects , Delayed-Action Preparations , Dose-Response Relationship, Drug , Female , Humans , Male , Middle Aged , Olanzapine , Patient Acceptance of Health Care , Psychiatric Status Rating Scales , Treatment Outcome , Weight Gain/drug effects
18.
J Clin Psychiatry ; 64(2): 119-22, 2003 Feb.
Article in English | MEDLINE | ID: mdl-12633119

ABSTRACT

BACKGROUND: Patients with chronic schizophrenia (DSM-IV criteria) often receive depot antipsychotic medications to assure longer administration and better compliance with their treatment regimen. This study evaluated whether patients stabilized on depot antipsychotic medication could be successfully transitioned to oral olanzapine. METHOD: In a 3-month open-label study, 26 clinically stable patients with schizophrenia taking depot antipsychotics for over 3 years were randomly assigned to continue on their current depot dose or to switch to oral olanzapine. Clinical ratings (Positive and Negative Syndrome Scale [PANSS], Global Assessment of Functioning [GAF] scale, and Clinical Global Impressions [CGI] scale) and side effect parameters (Abnormal Involuntary Movement Scale [AIMS], Barnes Akathisia Scale, AMDP-5 scale, vital signs, and weight) were obtained monthly. RESULTS: Oral olanzapine patients (N = 13) demonstrated significant clinical improvement over the depot control group (N = 13) from baseline to 3-month endpoint (PANSS total, p =.012; PANSS general, p =.068; PANSS negative, p =.098; CGI-Improvement, p =.007; CGI-Severity, p =.026; GAF, p =.015). Side effect rating scales showed no statistical differences between the 2 groups (AIMS, Barnes Akathisia Scale, AMDP-5, vital signs). The depot control group showed no statistical superiority in any measure except weight change (p =.0005). After 3 months, all olanzapine patients preferred olanzapine to their previous depot medications and chose to continue on olanzapine treatment. CONCLUSION: Clinicians may expect clinical improvement when switching chronically psychotic patients from traditional depot antipsychotic drugs to oral olanzapine. Switching may be completed within a 4-week period with relative compliance being maintained and patients preferring oral olanzapine to their previous depot medications.


Subject(s)
Antipsychotic Agents/administration & dosage , Pirenzepine/analogs & derivatives , Pirenzepine/administration & dosage , Schizophrenia/drug therapy , Administration, Oral , Adolescent , Adult , Aged , Antipsychotic Agents/therapeutic use , Benzodiazepines , Chronic Disease , Clozapine/administration & dosage , Delayed-Action Preparations , Female , Humans , Male , Middle Aged , Olanzapine , Patient Compliance/psychology , Pirenzepine/therapeutic use , Psychiatric Status Rating Scales , Schizophrenia/diagnosis , Schizophrenic Psychology , Treatment Outcome
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